Advances in the identification of gastro intestinal stromal tumors its molecular and immune histochemical basis and its management have been water shed in the treatment of gastro intestinal stromal tumors. Gastro intestinal stromal tumor (GIST) is now defined as a specific KIT expressing and KIT signalling driven mesenchymal tumor of gastro intestinal tract. The Imatinib drug which blocks the C–KIT receptor shows remarkable efficacy in the treatment of GIST.

We hereby report a case of GIST in 47 years old male complaining of abdominal pain since 6 months along with palpable mass involving whole of abdomen. It was confirmed on Usg, CT Scan and true cut biopsy. Laparotomy revealed a solid cystic mass 28 x 30 x 26 cm in size weighing 3 kgs that was well defined arising from greater curvature of stomach. Complete tumor resection was performed. Histopathological examination revealed features of GIST. It was CD 117 positive and DOG positive