The  aim  of  the  present  study  is  comparison  of  glutamine  and  probiotics  as  a  nutrition  supplement  in  patients  with  sepsis  in  terms  of  Length  of  hospital  stay, Mechanical  Ventilaton  free  days, Mortality rate, Frequency  of  infectious  complications. The  final  sample  comprises  of  120  patients– 60  patients  in each  group  on  the  basis  of  quota  system  i.e  patients  receiving  glutamine  and  probiotics  as  standard diet. One  sample  of  10 ml  blood  sent  for  culture/sensitivity  as  to  clinically  diagnose  septicemia, and second  sample  of  10 ml  blood  for  culture/sensitivity  after  two  weeks  of  enteral  feed. They  are evaluated  by  history, clinical  examination  and  relevant  investigations. Group 1  will  receive  glutamine 30gm/ day  and  Group 2  will  receive  probiotics  10 billion CFU/day. This  prospective, clinical  study  was designed  to  detect  differences  in  clinical  outcomes  between  two  enteral  formulas  after  admission  to  an ICU. There  was  marked  reduction  in  length  of  hospital  stay  with  patients  receiving  enteral  glutamine in  comparison  to  probiotics. There  was  no  significant  difference  in  mechanical  ventilator  free  days &  frequency  of  infectious  complications  in  between  patients  receiving  enteral  glutamine  and  probiotics. There  was  significant  difference   in  mortality  between  two  groups   i.e  mortality  rate  decreases   more  in  patients  receiving  enteral  glutamine  supplementation  than  probiotics. Our  study  therefore  concludes  exogenous  enteral  glutamine  supplementation  in  sepsis  patients  have  shown  benefits  related  to  anti–inflammatory  roles,  immune  modulation,  preservation  of  tissue  function  and  antioxidant  capacity