ABSTRACT

IJSR

International Journal of Scientific Research

2277 - 8179

Indian Society for Health and Advanced Research

ijsr-8-2-17950

Original Research Paper

Accuracy and impact of GeneXpert MTB/RIF assay for the diagnosis of smear-negative tuberculosis using bronchoalveolar lavage fluid in a tertiary care hospital in Kolkata, India

Mandal

Dr. Payel

Chakraborti

Dr. Ajoy

Krishna Sarkar

Dr. Sutirtha

Chakraborty

Dr.

February 2019

8 2 01 02 ABSTRACT

Early detection is mainstay for tuberculosis treatment. Fifty–nine of 148 smear–negative bronchoalveolar lavage samples detected very low concentrations of M. tuberculosis in GeneXpert assay (38.86%); 56 were cultured on extended incubation and grew M.tuberculosis. Seven showed Rifampicin resistance(4.73%) by GeneXpert assay also confirmed by phenotypic method. The sensitivity, specificity, PPV, NPV of GeneXpert were 100%, 96.74%, 94.92% and 100% respectively