Objective: – This study was done to compare efficacy of platelet rich plasma and normal saline dressing of non healing trophic ulcer in patients of Hansen´s disease.

Methodology: – 50 cases of non healing trophic ulcer in patients of Hansen’s disease were included (M:F=1.5:1) and divided into two groups (PRP group & Normal saline group). Dressing of PRP group with normal saline and PRP injected at wound base and margin at different interval, dressing of normal saline group with normal saline only. Outcome was compared by assessment of wound area and PUSH score over a period of 6 weeks.

Result: – PRP group showed significant decrease in area of wound and PUSH score as compared to normal saline group at the end of study. There is no significant complication during study period in both groups.

Conclusion: – Use of PRP in dressing of trophic ulcer has enhanced healing reduced duration of treatment, and improving the patient’s quality of life.