Chronic Suppurative Otitis Media (CSOM) is a major health problem in developing countries. Most common organisms associated with CSOM are Staphylococcus aureus and Pseudomonas

Clindamycin is very effective against staphylococcal isolates causing CSOM

Resistance (Constitutive or Inducible) to Clindamycin may result in treatment failure. Inducible Clindamycin resistance cannot be determined using standard susceptibility test methods but by Double disk diffusion test (D–test).

Present study was undertaken to provide baseline data on inducible Clindamycin resistance among Staphylococcal isolates from CSOM patients in our area.

Total 157 patients having CSOM were included in the study.

Aerobic bacteriological culture yielded 67 staphylococcal isolates. Inducible Clindamycin resistance was detected in 9.8% Methicillin susceptible Staphylococcus aureus (MSSA), 28.57% Methicillin resistant Staphylococcus aureus (MRSA) and 12.5% Methicillin susceptible coagulase negative Staphylococci (MSCONS).

Detection of inducible Clindamycin resistance can help in using the drug safely and effectively.