Background: It is estimated that about 1.1% of the adult women in India are engaged in sex work. FSW are potential risk group.  Hepatitis C virus (HCV) and Human immunodeficiency virus (HIV) have shared routes of transmission so a frequent occurrence of HIV–Hepatitis co–infections in seems likely. Method: Study was carried out from August 2014 to July 2016. 500 Sera samples were tested for HCV and HIV antibodies, out of which 250 sample were of brothel FSWs and 250 samples of were healthy female blood donors. Results: Seropositivity of  HCV infection was found to be 1.20% and 0.40% respectively. HIV infection is 0.80% for both groups individually. While none of FSWs and female blood donor were coinfected with both the infections.   Conclusions: Low prevalence among study area suggests that Targeted intervention among this risk group is effective measure in decreasing the HCV and HIV co–infection rate.