Background: Retinopathy of prematurity (ROP), а vasoproliferative retinal disorder, is an important cause of visual impairment in premature neonates and infants.

Objectives: The primary objective was to study the correlation of Retinopathy of Prematurity with gestational age, birthweight, oxygen delivery and clinical staging.

Methods: Study was conducted at the neonatal intensive care unit of a private tertiary care hospital in Navi Mumbai from September 2015– September 2017 wherein 54 inpatients who were < 34 weeks of gestation and < 1500 grams birthweight were taken. A detailed history, clinical examination and an ophthalmological screening at 3 – 4 weeks of chronological age was undertaken and recorded

Results: All neonates revealed ROP, with maximum in 28 –30 weeks of gestation, 1000 – 1500 grams birthweight and in Stage 2 ROP and Zone 2 ROP. Major risk factors were Respiratory Distress Syndrome, Anaemia, Metabolic Acidosis and Sepsis.

Conclusion: The duration of oxygen therapy and FiO2 delivered were directly proportional to the severity of ROP staging and judicious use of monitored oxygen therapy would be mandatory for the prevention of ROP.