Artifacts are very common and bound to occur during microscopic preparation and may be caused in various ways. A histopathological tissue under goes various laboratory steps before it is kept on the diagnostic table for confirmatory diagnosis. This procedure is not only lengthy but also technique sensitive. Hence some unintentional technical errors introduced in the slide preparation may pose and enigma to pathologists. This article reviews the most common artifacts encountered by pathologists in their day to day life with their remedies.