Cryosurgery is a simple and definitive method to treat  intraoral leukoplakia. A series of 50 patients, with oral leukoplakia (Histopathologically proven) on the lower lip, buccal mucosa, labia mucosa and tip of the tongue, were treated by direct application of nitrous oxide with a cryogen. Each lesion was exposed to two cycles composed of freezings of 60s and thawing of double of the freeing times. Lignocaine gel was used as transferring media. All lesions had disappeared completely 2–4 weeks after one or two treatment courses of cryosurgery. In all cases, neither scarring nor infection was noted during  3 months to 6 months of follow–up.