Transient isolated unilateral hypoglossal nerve palsy is rare diagnosis in clinical practice and various etiologies have been depicted in studies across the world. The sign and symptoms are milder than other palsies but it can be persistent or transient. There have been very few published single case reports on hypoglossal nerve involvement and case series are even fewer and we report a case of a transient isolated unilateral hypoglossal nerve palsy associated with Herpes Simplex Virus infection presented at SGT medical college, hospital and research center.