Thrombophilia, both acquired and inherited have been shown to be associated with severe pregnancy complications. Unexplained multiple pregnancy loss subject are evaluated with detailed history procurement, endocrine dysfunction tests, anatomic abnormality detection and data of the functional level of Heritable Coagulation Inhibitors, then analyzed statistically with similar data from age matched controls, so as to assess the impact of the abovementioned factors, in general, and the impact of the altered level of Heritable Coagulation Inhibitors, in particular