Waste water originated from domestic and industrial discharge. External contact and ingestion of bacteria from fecal contamination can cause disturbance in Health. E.coli is one of most common bacteria in human intestinal tract. It is known as fecal contaminant in water and food. The bacterium E.coli is one of the best free living microorganisms. E.coli is not a pathogenic but occasionally it causes traveler’s diarrhea, food born disease and urinary tract infection. Due to various hazardous effluents mixed in the water this common bacterium is showing multidrug resistance property which is great risk for human health, in this context we isolates 25 E. coli bacterial isolates and identified it as drug resistance bacteria against six antibiotics