Introduction: Chronic kidney disease (CKD) is one of the common serious health problem associated with increased morbidity and mortality, especially in developed countries. Progression of CKD is associated with having a number of complications, including thyroid dysfunction, dyslipidemia and cardiovascular diseases. This study was conducted to investigate lipid profile in CKD patients.

Methods: The present study was a prospective observational study conducted on 150 adult patients of CKD, 50 each from stage 3, 4, and 5 on regular follow up of kidney and dialysis clinic. Demographic features and medical history of diabetes mellitus, hypertension and cardiovascular diseases of each patient were noted, and blood samples were analyzed for serum urea, creatinine, total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol and triglyceride 

Results: In our study hypertriglyceridemia was found in 37%, hypercholesterolemia in 36%, low HDL in 36%, high LDL in 36%, and high VLDL in 36% of the patients. There was a significant rise in LDL and VLDL, and significant decrease in HDL from CKD stage 3 to 5.  

Conclusions: CKD patients have increased risk of CVD and higher prevalence of dyslipidemia as compared to the general population. The majority of patients die because of cardiovascular related moratlity before even reaching to the ESRD. Therefore it is necessary to identify dyslipidemia in early stages to prevent the further progression of kidney dysfunction, leading to better quality of life and improved morbidity and mortality. So, regular checkup of lipid profile is recommended in patients with CKD.