IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-8-2-18121 Original Research Paper Spot Urine Uric acid level in asphyxiated term newborns Darshan Kataria Dr. February 2019 8 2 01 02 ABSTRACT

Introduction– Perinatal asphyxia is a condition defined as hypoxemia, hypercapnea and acidosis in neonate. Cellular hypoxia leads to increased excretion of uric acid.Aims & objectives– To compare urinary uric acid levels within 48 hours of birth among asphyxiated and non–asphyxiated term newborns.Material and methods–

Study design– Prospective observational cohort study

Settings– Tertiary level hospital in central India

Duration– July 2017 to June 2018.

Participants– Due to financial constraints 100 neonates were enrolled.

Statistical analysis was performed by IBM SPSS version 22 and Microsoft Excel. Test of significance by Mann–Whitney U test.Results– The mean rank of urine uric acid (32.76vs 20.29) was significantly higher in term newborns as per asphyxia (p=0.005).Conclusions– urine uric acid=16.10 micromole/24 hr has a sensitivity (61.4 %), specificity (72.2%) for detecting asphyxia in term newborns