Lycopene is a carotenoid phytochemical antioxidant found in tomatoes. Oxygen derived free radicals are the most reactive species cause oxidative stress. It is one of the major causes of osteoporosis with increased lipid peroxidation, distorted osteoblastic cell activity and antioxidant status. Supplementation of lycopene improves antioxidant status by maintaining osteoblastic cell activity because it has a singlet oxygen quenching ability twice as high as that of β–carotene and 10 times higher that of α–tocoferol therefore believe to improve the condition of osteoporotic patients. The present study included 60 clinically diagnosed osteoporotic patients, age between 40–60 years.60 patient matched healthy subjects were taken as control. After estimation of base line osteoblastic markers including ALP, Pi and Ca⁺⁺, lipid peroxidation product MDA, oxidative stress biomarkers like SOD, GPX, GR, GSH, antioxidant vitamins A, C and E, patients supplemented 180gm of tomato products. After 90 days of lycopene supplementation patients were reassessed for all biochemical parameters included in the study.The results of study revealed increased ALP while decreased Pi and Ca⁺⁺ in osteoporotic patients but after lycopene supplementation levels were improved without any significant change in inorganic phosphorus. Decreased lipid peroxidation and oxidative stress were confirmed by MDA and recovered levels of SOD, GPX, GR, GSH, Vitamin A, Vitamin E and Vitamin C respectively in patients. The results of present study concluded that dietary intake of tomato lycopene is beneficial for bone health in osteoporotic patients as it acts as an external antioxidant to fulfill the body need. It is confirmed by improved levels of osteoblastic markers and antioxidants after lycopene supplementation