Periapical lesions are the lesions pertaining to the tissues around the apex of a tooth root, including the periodontal membrane and the alveolar bone. These are often diagnosed on clinical and radiological basis that may be different from the histological finding. The lesions most commonly found at the apices of non–vital teeth are the periapical granuloma and radicular cyst. A variety of lesions can mimic the pulpo–periapical lesions radiographically for example odontogenic keratocyst, periapical cementosseous dysplasia, benign tumors and locally aggressive or malignant neoplasms