Background: The aim of the study was to find the prevalence of anxiety and depression in COPD patients as undiagnosed cases may have an negative impact on the overall health status and find its correlation with factors like age, gender, disease severity and health related Quality of Life (QOL). Method: 226 subjects enrolled in this study. Basic demographic details were gathered. Hospital Anxiety and Depression Scale (HADS) was used to assess anxiety and depression. QOL was assessed using St. George’s Respiratory Questionnaire (SGRQ). Result: Prevalence of anxiety and depression in COPD subjects in the study was 35.4% and 52.7% as per HADS questionnaire. Age and SGRQ score showed a significant positive correlation whereas disease severity showed a significant negative correlation with anxiety and depression. Association of the anxiety and depression with gender showed anxiety to be statistically significant in males and females. Conclusion: Higher rates of depression and anxiety symptoms are seen in patients with COPD even in earlier stages of the disease.