IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-8-3-18231 Original Research Paper Correlative study of Ferric Reducing Ability of Plasma (FRAP) an oxidative stress marker and Serum Iron level in pregnant anaemic women in three trimesters of pregnancy Panjeta Dr. Rimpy Charak Dr. March 2019 8 3 01 02 ABSTRACT

Oxidative stress (OS) results from an imbalance between reducing agents and enzymes involved in the removal of free radicals and/or reactive oxygen species. Oxidative stress has been a source of great interest among researchers during the last decade and not without reason. Increased oxidative stress has been shown to be involved in the pathogenesis of a large number of disease processes directly or indirectly. Pregnancy favours a pro–oxidant environment mainly due to the mitochondria–rich placenta. Oxidative stress may not just be a threat to the mother but also to the growing fetus. Further anaemia is also a pro–oxidant condition and females in developing nations like India, suffer from mild to moderate anaemia which further worsens during pregnancy. In the rural female population, this problem is more acute keeping in mind that their diet is deficient in a wide array of nutrients including iron. Material and Method: The objective of the study is to find a correlation of ferric reducing ability of plasma (FRAP) an oxidative stress marker and iron level in pregnant anaemic women in three trimesters of pregnancy. For this, a study group included a total of 150 subjects. All subjects were divided into control and study groups. Control group consisted of 25 non–anaemic pregnant women of the 1st trimester in 1st group, 25 non–anaemic pregnant women of the 2nd trimester in 2nd group and 25 non–anaemic pregnant women of the 3rd trimester in the 3rd group. While the study group consisted of 25 anaemic pregnant women of the 1st trimester in 1st group, 25 anaemic pregnant women of the 2nd trimester in 2nd group and 25 anaemic pregnant women of the 3rd trimester. Control and study group divided based on different trimester. Results: Showed a direct positive correlation between Serum Iron levels and Ferric Reducing Ability of Plasma (FRAP) an Oxidative stress marker in the study as well as the control group. Conclusion: Anemia in pregnancy shifts the oxidant–anti oxidant balance towards the oxidant spectrum resulting in a significant decrease in antioxidant activity in plasma of such females. This adds to the already existing pro–oxidant environment caused by the pregnancy. With oxidative stress already implicated in maternal and fetal complication in the outcome of pregnancy, this increase is significant and calls for further evaluation