The morphology of normal red cell is biconcave disc–shaped that measures about 7–8 µm in diameter, has central pallor which is approximately one third of the red cell diameter and lacks intra–cytoplasmic inclusions. Red cells are pink in color when stained with Rowmanosky dye because the haemoglobin content of the red cell picks up eosin, the acidophilic components of the dye. Abnormal variations in cell size, shape, color, presence of intracellular inclusions and pathologic arrangement of the cells suggests a host of abnormalities. We present a case of patient with sepsis uncovering echinocytes in peripheral blood smear.