Ewing sarcoma family include typical, atypical ES, Peripheral primitive neuro ectodermal tumour and Askin tumour occuring during first two decades of life , the most frequent sites,being femur,tibia, ilium and fibula. Materials and methods: A Prospective,descriptive study with 3444 fine needle aspirates revealed 61 bone lesions . Primary malignant bone tumours 37 (61%) and ES were 9 cases (15%). Results: The median age of the patients were 17years ,M: F ratio 1.2: 1, with swelling and pain mimicking osteomyelitis.Aspirates showed dispersed cells with an admixture oflarge pale andand small round cells. Histopathology revealed sheets , lobules and pseudo rosettes of small uniform round cells separated by thin fibro vascular septae.In two cases with metastases, an intense membranous positivitywith CD 99 and NSE was positive in Askin tumour. Conclusion: An accurate, specific cytodiagnosis supplemented with IHC and Cytogenetics helps an early therapeutic protocol to be implemented.