Background: Cancer is one of the leading causes of mortality & morbidity worldwide. Cancer patients experience symptoms including pain, fatigue and various mental distresses. Scientists have proven the cancer healing abilities of Graviola in patients with breast, liver, pancreatic cancer. Investigator has witnessed the dramatic effect of Graviola on liver cancer patient at USA and recommended the same to the patients in India. Hence the investigator decided to conduct the study in phase I and Phase II. Objectives: The aim of the study was to determine the impact of Graviola on QOL of cancer patients and to correlate the use of the Graviola with disease & selected background factors. Methods: Design used was Ex post facto Quasi Experimental. Baseline data from 164 patients with cancer and who were consuming Graviola were analyzed using Standardized tool for QOL – EORTC–QOL–C#) and Opinionnaire on Graviola. Data was collected by telephonic interview survey technique after obtaining oral consent. Result: Majority of the sample belonged to the age group of 46–60 years. 56.7% of the sample did not have trouble in doing strenuous activities. Only 3% had trouble in taking a long walks whereas 62% of the sample did not require any help with ADL. 62% of the sample showed significant reduction in pain. 90% sample stated that their sleep quality had been improved, 80% of the sample vocalized that all gastro intestinal problems such as lack of appetite, nausea, vomiting, diarrhoea were reduced. 58% sample stated there were significant reduction in feeling of anxiety, worry, and tiredness. Conclusion: The use of Graviola has significant effect in improving QOL. However further extensive researches are required to elicit the endpoint benefits of Graviola which can be a boon for cancer patients