Introduction: Chronic liver disease is defined as hepatic parenchymal injury and fibrosis which is associated with development of regenerative nodules Materials and Methods: 50 patients of chronic liver disease without any intrinsic cardiopulmonary disease enrolled in the study. All the patients subjected to the Routine Investigation, LFT, UGI Endoscopy, ECG, Ultrasound Abdomen, and Speckle Tracking Echocardiography. The patients were divided in two groups according to their MELD score and group A was MELD <10.5 and group B MELD >10.5. Results: Mean longitudinal strain and strain rate between group A and B was statistically significant (P Value <0.001). Mean circumferential strain and strain rate between group A and B was statistically significant (P Value <0.001).Conclusion: Higher the MELD score, higher the longitudinal and circumferential strain and strain rate. Speckle Tracking Echocardiography is an important tool to assess the subclinical left ventricular dysfunction in chronic liver disease