Introduction: Epilepsy is the most common neurological disorder in pediatric age group.[1] Due to ethical issues, data about safety and efficacy of Antiepileptic drugs (AEDs) in pediatric patients is limited. Therefore, our study was conceptualized to obtain baseline data on prescribing pattern and safety profile of antiepileptic drugs in pediatric patients. Material and Methods: This was a prospective cross–sectional study, conducted from November 2016 to October 2017 in the Department of Pharmacology and Pediatrics our teaching hospital. Result and Summary: Out of total 207 patients, majority was males and the most common age group affected with seizure disorders was 1–5 years. Monotherapy of antiepileptic drugs (83.1%) was significantly prescribed whereas valproate was the most commonly prescribed AED in the current study. The rate of occurrence of adverse drug reactions was lowest for valproate utilization. The WHO–UMC causality was found to be probable (53.3%) for maximum ADRs.