Aim: To study the severity of anemia and to categorize the patterns of anemia in patients infected with HIV.Materials and Methods: This is a prospective study carried out in the Department of Pathology, GMKMC, Salem for a quarterly period in 2018. Venous blood samples were collected from HIV infected patients, subjected to Complete hemogram analysis and peripheral smears were made.Results: In our study group of 200 HIV infected patients with anemia, mean hemoglobin concentration was 9.5 g /dl. Mild Anemia was seen in majority of the patients (50.5%). The most common pattern of anemia was Normocytic Normochromic Anemia seen in 83 patients ( 41.5%).Conclusion: Anemia in HIV patients is a predictor of disease progression. Early detection and treatment of Anemia in HIV patients is mandatory to reduce the Morbidity and Mortatlity.