Introduction: Acute pancreatitis (AP) is a protean disease with dynamic imaging characteristics & a broad clinical spectrum of findings varying from mild to severe. AP and its complications are recognized as an important cause of morbidity & mortality in hospitalized patients. CT is the imaging method of choice for assessing the extent of acute pancreatitis, its complications and subsequent management. Aims and Objective: 1) To evaluate the AP on Computed Tomography and grade the severity as per modified CT Severity Index. 2) To correlate the modified CT Severity Index with patient outcome.3) To evaluate the etiological factors of acute pancreatitis. Materials and Methods: A hospital based prospective study was conducted from November 2016 – April, 2018 on 50 IPD patients referred to the Department of Radio diagnosis with findings suggestive of AP. Patients underwent NC & CECT. Severity of pancreatitis was scored using MDCTI. Outcome parameters included the length of hospital stay; the need for surgery or percutaneous intervention; and the occurrences of infection, organ failure (OF), and death. Pearson chi square test and Fisher’s exact test were performed. Results: We included 50 cases [30 males & 20 females, age range 17–69 (mean 40.16± 14.08 years]. Chronic alcohol abuse was the most common etiological factor seen in 44% cases followed by cholelithiasis seen in 34% cases. According to MDCTI, 4% patients had mild, 64% patients had moderate and 32% had severe pancreatitis. Modified CT severity score was found to be significantly correlated with organ failure (p=0.005), systemic infection (p < 0.001), duration of hospital stay (p=0.020) and need for surgery or intervention (p=0.017). Conclusion: Modified CT severity index is a good prognostic indicator of clinical outcome of patients with acute pancreatitis and showed significant correlation with all the clinical outcome parameters.