IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-8-3-18436 Original Research Paper Evaluation of Nalbuphine in SAB with 0.5% Hyperbaric Bupivacaine - A double blind randomized study I. Ravi Mohan Dr. Dr. Srividya D Dr. March 2019 8 3 01 02 ABSTRACT

Background and Aim: Spinal opiate analgesia is popular. The analgesia is intense and useful post operatively also. The rescue analgesia is minimal or can be avoided totally depending on the type of opiate. Aim: To evaluate the efficacy of combination of nalbuphine 0.8mg with hyperbaric bupivacaine 0.5% compared to hyperbaric bupivacaine 0.5% with normal saline intrathecal route in providing pain relief Intraoperatively and extending into the post operative period, in lower abdomen and orthopaedic procedures. Methods: 50 patients of ASA grade I and II physical status belonging to both the sexes scheduled for lower abdominal and orthopaedic surgeries .Patients were divided into two groups B and N randomly. GROUP B hyperbaric bupivacaine 0.5% 2.5ml(25mg)+normal saline 0.9% 0.5ml.GROUP N hyperbaric bupivacaine 0.5% 2.5ml(25mg)+ nalbuphine 0.8mg(0.5ml) Results: No sedation in group B. Sedation was noted in group N (0.5% hyperbaric bupivacaine+ nalbuphine).Onset of sensory block was faster in group N than in group B. Onset of sensory action was in the range of 3 to 6 min in group B and in range of 2 to 3min in group N. Onset of motor block was only slightly faster in group N than in group B. Conclusion: Addition of 0.8mg (0.5ml) of nalbuphine to hyperbaric bupivacaine 0.5% 2.5ml when compared to hyperbaric bupivacaine + normal saline causes definite prolongation of analgesia with minimal sedation.