Background: Euvolemic hyponatremia is associated with syndrome of inappropriate antidiuretic hormone secretion, hypothyroidism and adrenal insufficiency , which are often overlooked in clinical diagnosis. Aim: Evaluation of proportion of thyroid and adrenal derangement in patients with hyponatremia and correlate this with Severity of Hyponatremia and Plasma osmolarity. Material and Method: A Hospital based cross sectional study was conducted with 60 clinically diagnosed euvolemic hyponatremia patients without co–morbidities .Thyroid profile and cortisol levels were estimated . Results: A significant difference in the osmolarity and sodium levels was found in cases as compared to control. Nineteen patients had thyroid derangement (17/19 cases having hypothyroidism ) frequently seen in severe grade hyponatremia . Cortisol level was found low (<28ng/ml) in 24 /60 patients predominantly in Moderate hyponatremia (08/29). There was a negative association between sodium and parameters like TSH, Cortisol, uric acid and a positive association with total protein. Conclusion: Patients with euvolemic hyponatremia should be thoroughly investigated for adrenal and thyroid hormone status to reach to an etiological diagnosis