Introduction: Chronic kidney disease is a worldwide health problem. Chronic Kidney Disease is associated with several abnormalities in the gastrointestinal tract involving all its segments. Many of these abnormalities produce serious life threatening situation, few produce serious important clinical symptoms, while others produce only subclinical functional alterations. These findings suggest that neither hyperacidity, hypergastrinemia nor H. pylori play a major role in the pathogenesis of uremic gastro duodenal lesions. Impaired mucosal cytoprotection has been postulated but not proven. Materials and Methods: A total number of 230 chronic kidney disease (CKD) patients admitted to Govt: Medical College Jammu between March 2018 to February 2019 was selected in this study. Results: The majority of the patients belong to 21–30 years age group, of which 60 were males. There were 54 patients in 31–40 years age group with males far more than females.UGI finding were seen in 166 (72.17%) patients. The most common lesion seen was Erosive Gastritis (28.7) followed by Erosive esophagitis (27.4%) and then Duodenal ulcer (17.4%) . Conclusion: Majority of the patients of CRF have UGI mucosal lesions on endoscopic evaluation. Erosive mucosal disease is the most common form of GI pathology in CRF.