Histoplasmosis is a disease of immunocompromised and has a low incidence. Primary Laryngeal Histoplasmosis is a rare condition. Less than 100 cases of laryngeal histoplasmosis have been described in the medical literature. Isolated laryngeal involvement leads to the misdiagnosis and mistreatment of tuberculosis or laryngeal cancer. The development of hoarseness in a patient with histoplasmosis or a laryngeal mass leading to hoarseness should be seen with suspicion. The diagnosis becomes more difficult when it presents as a primary disease. Biopsy is prerequisite for diagnosis