Elevation of Troponin T and N–Terminal pro–B–type natriuretic peptide (NT–proBNP) are commonly and strongly predictable biomarkers of Heart Failure (HF) patients with CKD. The present study included 150 people with CKD. We examined the association of baseline levels of elevation of TnT and NT–pro BNP with Heart Failure (HF) and CKD patients, after the adjustment for demographic factors, traditional cardiovascular risk factors and biomarkers of Chronic Kidney Disease. Constant medication application and mineral metabolism biomarkers cause Heart Failure and CKD. At base line, elevation of TnT levels ranged from <_5.0 to 1000 pg/ml and NT–proBNP levels ranged from <_5.0 to 35000 pg/ml. Compared to normal controls for TnT <_5.8 – 25.8 pg/ml and NT_proBNP 54 – 340 pg/ml. With this conclusion the elevation of TnT and NT–prBNP were strongly associated with incident of Heart Failure (HF) among with severe CKD. Elevations in these biomarkers may indicate subclinical changes in volume and myocardial stress that subsequently contribute to clinical Heart Failure (HF) with CKD.