Diabetic patients are prone to develop coronary artery disease. Low degree of inflammation may play central role in type 2 diabetes & CAD. Aim: To find significance of inflammatory markers in T2DM with & without CAD. Material and method: Total 210 subjects including control, T2DM with & without CAD were assessed for hsCRP, IL6 & TNFα. Patients with chronic renal/liver diseases & inflammatory disorders were excluded. Study was approved by institutional Ethics Committee & statistics done on SPSS–20, Chi–square & Independent t–test applied, *p <0.05 Result: Significant increased inflammatory mediators, due to cytokines released by monocytes/macrophages which initiate process of β cell damage. hsCRP, IL6 & TNFα induces local inflammation & independently predict atherosclerotic burden manifested by number of obstructed vessels & its severity. Conclusion: Our study highlights inflammatory mediators are strong indicator for future risk & severity & CAD in DM