INTRODUCTION; Dengue is a mosquito borne Arboviral disease caused by the dengue virus. The global prevalence has grown dramatically (1) in the recent decades. The WHO estimates that 40% of the world’s population (about 2.5 billion) living in the tropical and sub tropical areas are at risk AIMS AND OBJECTIVES:To evaluate hematological changes in patients suffering from clinical manifestations of dengue with serological confirmation. . To correlate hematological findings with the clinical findings and whether the progression could be predicted. MATERIAL &METHOD–A commercially available Dengue NS1 Ag & Ab combi–card test kit is used to detect NS1 antigen and IgM and IgG antibodies. Evaluation of hematological and serological parameters is done by collecting 2 ml of sample on EDTA and plain bulb respectively. RESULT–The study included 100 patients with seventy (60%) male and thirty (40%) female patients. The ages of the patients ranged from 12 to 75 years. Seventy patients were in the age group of 21 to 40 years. In this study the male to female ratio of patients was 2.3: The most common clinical features were fever. mean level of SGOT & SGPT were higher in those with shock than those without. . Sixty nine patients in this study had a platelet count of less than 50,000/µL at presentation. CONCLUSION– The most common clinical features were fever, males are more commonly affected than female. Hepatic dysfunction was common in dengue fever. Thrombocytopenia is the most common hematological finding in patients with dengue infection..