Introduction– Perinatal asphyxia is a condition defined as hypoxemia, hypercapnea and acidosis in neonate. Cellular hypoxia leads to increased excretion of uric acid. Aims & objectives– To compare urinary uric acid levels within 48 hours of birth among asphyxiated and non–asphyxiated preterm newborns. Material and methods– Study design– Prospective observational cohort study Settings– Tertiary level hospital in central India Duration– July 2017 to June 2018. Participants– Due to financial constraints 100 neonates were enrolled. Statistical analysis was performed by IBM SPSS version 22 and Microsoft Excel. Test of significance by Mann–Whitney U test. Results– The mean rank of urine uric acid (13.13vs 11.40) was not statistically significant in preterm’s as per asphyxia indicator (p=0.561). Conclusions– urine uric acid levels were not consonant with birth asphyxia.