Use of biomarkers is a routine clinical practice in medicine to provide objective evidence of normal and pathological biological process, response to therapeutic interventions and relapse of disease. However, in field of psychiatry, clinicians mainly rely on clinical interview and psychological tools for diagnostic and therapeutic purposes. Inflammatory biomarkers present a valuable and promising aid to advance better understanding of pathogenesis, diagnosis, treatment and prevention of depression. This review provides a summary of available literature on inflammatory biomarkers in major depression with specific focus on peripheral inflammatory biomarkers which have a potential to be easily used in routine clinical practice