Background: The world has rapidly changed over the past few decades with the advent of mobile phones. Almost seven billion mobile phones are now used worldwide, of which over five billion are in developing countries. Mobile phones emit low levels of radiofrequency energy (RF).The widespread usage of mobile phones in recent years has raised concern for potential dangers and subsequent research activities. Most of the studies on mobile phone radiation and its biological effects are short–term exposure studies with varied results. No formal studies examining the changes in blood parameters of human associated with mobile phones have been found in the medical literature to date. Study of changes in blood parameters due to excessive use of mobile phones was rare and is first of its kind in our community. Objectives:The present study was conducted with an objective to investigate whether excessive use of mobile phones are associated with any abnormal changes in blood parameters of users and comparing the data with those of non–users of mobile phones. Methods:The study was based on survey questionnaire consisting of four questions which adequately covered the information related to the topic basing on which we divided the population surveyed in to four groups from excessive users to non–users of mobile phones.The heart rate and blood pressure were measured with Digital Blood Pressure Monitor,Model CH–432B,Citizen ,Japan and complete blood count(CBC) were performed using an automated coulter counter ‘Sysmax machine” in in all participants.The data were accumulated and analysed. Result:From the study it was found that 22.6% people were using mobile phones more than sixty minutes in 24 hours time(excessive users),67.4% use daily but less than 60 minutes time,4.4% use mobile only occasionally not daily and 5.6% of people do not have mobile phones,do not know their use(non–users).It was found that tachycardia and hypertension both were common in excessive users of mobile phones in comparison to nonusers.Moreover among the excessive users the abnormal blood parameters observed were decrease Hb%,decrease TRBC,decrease TPC and increased red cell distribution width(RDW). Conclusion: In conclusion we found tachycardia,hypertension ,anaemia,thrombocytopenia and increased RDW were commonly associated with individuals who use mobile phones excessively.