To challenge the neuro and cardiotoxic properties of racemic bupivacaine 0.5%, newer drugs like levobupivacaine and ropivacaine have come. An attempt has been made to compare efficacy and post–operative analgesia of 0.5% levobupivacaine and 0.5% ropivacaine for below elbow surgeries using infraclavicular brachial plexus block. Sixty subjects undergoing upper limb surgery were randomized into 2 groups (groups L and R) of 30 each receiving levobupivacaine and ropivacaine. The major concerns were to study the onset and duration of sensory and motor blockade, and duration of analgesia. Onset of sensory and motor block was faster in Group L. Duration of sensory and motor blockade was longer in Group L.We found that both drugs are having the desirable blocking properties of bupivacaine with a greater margin of safety due to their reduced toxic potential.