The pulmonary dysfunctions due to sickle cell disease (SCD) are one of the leading cause of morbidity and mortality in pediatric age group specifically in central India (Chhattisgarh) which lies in Sickling belt. Obstructive and restrictive pulmonary changes develop in children with sickle cell disease, but reports conflict as to the type of change that predominates. This study conducted to evaluate pulmonary function tests in pediatric patients of SCD and to understand the pathophysiology & pattern of pulmonary functions. Total 75 patients from 10 to 14 year age were compared with 45 healthy controls. In the SCD group FVC, FEV1, PEF, FEF25%–75% and MVV were lower as compare to control groups in both sexes. Pulmonary function is abnormal in children with Hb–SS & AS. It is likely that abnormal pulmonary function reflects intrinsic lung disease in these patients and the mechanisms are more complex in this population than originally appreciated.