AIM: Uric acid an antioxidant prevent oxidative and neuronal death in Parkinson’s disease [PD] patients. In humans half of the antioxidant property of blood comes from uric acid. We analyzed Serum Uric Acid in controls and PD patients and its relation to stage and duration of disease. MATERIALS AND METHODS: Eighty nine PD patients with normal BMI attending our movement disorder clinic were analyzed with serum uric acid levels. Those having diabetes mellitus, hypertension, smoker, alcoholic, renal failure, obesity, anemia and drugs modifying uric acid were excluded from the study. Modified Hoehn And Yahr Staging was done. Eighty nine age and sex matched normal people were taken as controls RESULTS: Among 89 patients, 68 were males and 21 females. Uric acid levels found significantly reduced in PD compared to controls [5.13 VS 6.4]. Based on Modified Hoehn And Yahr staging 23{25.84%} patients belonged to stage I of,:32{35.95%} in stage II; 22 {24.72% } in stage III AND 12[13.48% } in stage IV. Serum Uric acid levels is found inversely related to staging and duration of illness CONCLUSION: Serum uric acid is significantly reduced in PD. It correlates with Modified Hoehn And Yahr Staging and duration of illness. Reduction in uric acid level is associated with increased risk of Parkinson’s disease[PD] and hyperuricemia acts as a neuroprotective marker from PD .Diet modifications ,iron, zinc supplements increase uric acid; their role in preventing and reducing the morbidity of PD to be confirmed with larger studies