Hand and foot mouth disease is extremely commonly encountered in our country. Development of erythematous papulovesicular rashes on the hand, foot, and mouth is the commonest presentation. Myocarditis, pulmonary oedema, aseptic meningoencephalitis, and even death are some of the complications. Therefore, early diagnosis of HFMD is of particular importance. This study tries to compare the values of liver function test and CRP in mild and severe cases of HFMD