Background : Therapeutic plasma exchange is an emerging modality of treatment in many immunological diseases and in particular neurological diseases. Our study aims to evaluate its effectiveness, tolerance and cost–effectiveness in our part of the world. Materials and methods: Patients admitted under neurology department and referred to blood bank for plasmapheresis during a period of 7 months from August 2018 to February 2019 in GMC (Government Medical College) Srinagar were included in the study. Results: A total of 73 procedures were conducted during this period on a total of 15 patients, which included one pediatric case of 13 years as well. Most common entity encountered was GBS. Very low complication rates were encountered in this study. Conclusion: TPE is an excellent modality for autoimmune neurological diseases especially in our resource limited setup.