BACKGROUND; Stroke is an important cause of disability and second most common cause of death, worldwide. Prognosis and final outcome in patients with stroke are significantly affected by complications occurring during acute phase of stroke. METHODS; This prospective study was conducted in Institute of Neurology & RGGGH, Chennai, for a period of one year in 100 patients with first ever ischemic stroke. Their detailed history, examination , hematological , biochemical parameters , complications were documented. Outcome at 30days post stroke was assessed using MRS score. RESULTS; 49% patients developed atleast one complications like constipation(41%), shoulder pain(31%), dysphagia(28%), UTI(24%), bed sore(23%), depression(22%), RTI(20%), haemorrhagic transformation with brain oedema(10%). CONCLUSION; Patients with complications were more likely to have poor outcome(87.8%) compared to patients without complications(54.9%).Hence early diagnosis and prompt treatment of these complications is needed, in order to improve the outcome and thereby the quality of life of patients after stroke.