Aim: This study was carried out to evaluate the changes in reticulin fibre network in endometrium with special stain to aid classification of histomorphology of endometrium in Dysfunctional Uterine Bleeding. Material and Methods This case control study was carried out among 100 women who were diagnosed with Dysfunctional uterine bleeding in our tertiary care medical college hospital between 2012 and 2015 with 25 normal endometrium with cyclical changes corresponds to LMP. Slides were stained with conventional Haematoxylin & Eosin, and Gomeri‘s silver impregnation method for reticulin. Results: Special stains are useful in emphasizing the architecture of normal endometrium and endometrial stromal abnormalities in DUB and also useful in demonstrating the spiral arteriole. In conventional H&E stain reticulin not easily detectable. Conclusion: This study has highlighted the changes in reticulin network with the help of special stain in the endometrial biopsy for an in depth analysis and categorization of DUB