Background: Propofol is one of the ideal anaesthetics that provides rapid onset of action, rapid recovery, easy titration with minimal side effects. Due to its side effect of causing pain while injecting, patient satisfaction is reduced with propofol. In this study we are comparing Lignocaine and Palonosetron to reduce pain on propofol injection during intravenous induction of anaesthesia. Material & Methods: Fifty patients of either sex between 18–60 years and ASA physical status I or II randomly allocated into two groups (n=25) to receive either Inj Lignocaine hydrochloride 40mg or Inj palonosetron 0.075mg as pre treatment to reduce pain on propofol injection. The pneumatic tourniquet was placed on same upper arm for 1 min to produce venous occlusion before giving drugs used for pre–treatment.The pain on propofol injection was assessed according to McCririck and Hunter scale: 0 = no pain, 1 = mild pain, 2 = moderate pain and 3 = severe pain. Results: Comparing pain during propofol injection, 60% in lignocaine group and 68% in palonosetron group did not have pain, 24% in lignocaine group and 20% in palonosetron group had mild pain, 12% in lignocaine group and 8% in palonosetron group had moderate pain, 4% in both groups had severe pain. No significant hemodynamic changes were observed in both groups. Incidence of post operative nausea and vomiting was less in group 2. Conclusion: Pretreatment with palonosetron is as effective as lignocaine in reducing the pain on injection of propofol with added advantage of reducing the incidence of PONV.