Introduction: The skin is the largest organ of the body, accounting for about 15% of the total body weight in adult humans. It exerts multiple vital protective functions against environmental aggressions .The fine structure of skin shows considerable regional variations, concerning its thickness (varying from 1 to 4 mm), distribution of epidermal appendages and density of melanocytes etc. Materials & Methods: The present study is a retrospective and prospective study conducted in Department of Pathology for a period of one year. Detailed clinical history, all other related investigations were considered. Patients’ history such as age, sex and other relevant clinical details such as site of lesion & character were noted/ provided by dermatologist. All tissue specimens were subjected to gross examination & all dimensions were taken from archives. Results: During the period of one year, total of 90 cases were studied.Among them inflammatory lesions were most common considering upto 40 cases, followed by Infectious 20 cases, non– neoplastic 17 cases and neoplastic 13 cases. Males are more commonly affected than females in our study. Age group between 31–40 years were most commonly affected. Conclusion: Histopathological diagnosis of each and every skin lesion should be considered ,because even minute swellings which can be considered as inflammatory or infectious may turn into neoplastic. So careful histpathological examination in association with dermatological findings and clinical details should be considered.