INTRODUCTION: The incidence of prostate cancer is on rise. It is fatal once it has spread outside the prostate. Therefore, it is important for early diagnosis of cases with prostatic enlargements and detect organ confined prostatic cancer. AIM: To study the efficacy of serum PSA and transrectal FNAC in the early diagnosis of prostatic growth. RESULTS AND OBSERVATION: FNAC showed 36 BPH, 04 prostatitis and 12 adenocarcinoma cases. sPSA level was found to be high in both benign and malignant cases. The sensitivity and specificity of the serum PSA found to be 100% and 85% respectively with a predictive value of 67%. CONCLUSION: Transrectal FNAC is a simple and safe procedure with high specificity & can be combined with sPSA estimation as a complementary investigative procedure.