Objective: Present study was conducted with intent to compare effects of addition of dexmedetomidine and midazolam as an adjuvant to local anaesthetic mixture in supraclavicular brachial plexus block. Material and methods: Three groups of 20 patients each. Control Group (Group–NS) 12.5 ml of 0.5% levobupivacaine + 12.5 ml of 2% lignocaine with adrenaline (1 in 200000) + 2.5 ml normal saline, study Group I (Group–DEX) 12.5 ml of 0.5% levobupivacaine + 12.5 ml of 2% lignocaine with adrenaline (1 in 200000) + 50 μg dexmedetomidine in 2.5 ml normal saline study Group II (Group–MID) 12.5 ml of 0.5% levobupivacaine + 12.5 ml of 2% lignocaine with adrenaline (1 in 200000) + 2.5 mg preservative free midazolam. Results: Onset and duration of sensory and motor block were comparable in test groups but were statistically significant when compared to control group. Sedation and satisfaction was greatest with midazolam followed by dexmedetomidine.