The aim of this study was to evaluate the anti–anxiety effects of aripiprazole in mice. 60 Inbred male adult albino mice were used in this study. 30 mice were divided in to five groups (n=6). Group I received normal saline .O, group II received diazepam 2 mg/kg P.O and the test groups III, IV and V received (1, 1.5, 2 mg/kg P.O) of aripiprazole.30 Mice were subjected to elevated plus maze test to evaluate the anxiolytic activity of aripiprazole. The locomotor activity was assessed in 30 mice using actophotometer to evaluate the CNS stimulant effect. The data was tabulated and analyzed statistically using one way ANOVA. Aripiprazole significantly increased the number of entries and the time spent at the opens arm. It did not increase the locomotor activity. Aripiprazole showed significant anxiolytic effects in mice. Further studies are needed to explore the anxiolytic activity of aripiprazole in humans.