Introduction: Dermatopathology is a unique branch of pathology, since it enables the clinician to directly view the patient’s gross pathology and, as a result the success of specialty often depends much upon careful clinicopathological correlation as it does upon histological features particularly. Aims and Objective: 1.To classify various non neoplastic lesions into categories that predicts clinically important attributes such as prognosis or response to therapy.2. Clinicopathological correlation to analyze the different nonneoplastic lesions of skin. Materials and Methods: A hospital based prospective study was conducted from June 2008 to May 2010 on 205 patients attending the outpatient Department of Dermatology & Venereology and Pathology with various non neoplastic lesions of skin.Biopsy of each lesion was done with routine procedure and histopathology was performed according to the study protocol including special stains. Results: Out of 205 patients clinicopathological correlation seen in 82.43% of the cases giving our significant p value of 2.2e–16 (which is much less then 0.0001).Vesiculobullous diseases found to be correlated clinicopathologically (77.14%) with p value of 0.000939 which is significant.Hundred percent correlations were seen in Photosensitivity Disorders, Metabolic Diseases of skin, Protozoan & Parasitic Diseases and Vascular diseases. Conclusion: Our study revealed that Clinicopathological correlation is highly significant in dermatopathology ,making accurate diagnosis in majority of non neoplastic skin disorders thus guiding appropriate treatment of patients and in assessing prognosis.