Background : DKA is a well known and major acute metabolic complication seen in diabetic pt (type 1 as well as type 2 ), if not recognized in initial stage it may turn into life threatening condition, characterized by hyperglycemia,acidosis and ketonuria , DKA can be inaugural or complicate known diabetes. Objective:THIS STUDY WAS PERFORMED TO EVALUATE BIOCHEMICAL PROFILE OF DKA PATIENT ADMITTED IN SHETH LG HOSPITAL Design: The study was a cross sectional study conducted over a period of 6 months in AMC MET medical college,Ahmedabad. Materials and Methods: Clinical profile of 50 diabetic pt admitted in emergency with the diagnosis of DKA were analysed. Results: Most common age group: 45–60 year Gender: male Mode of treatment: oral hypoglycemic agents>insulin Mean duration of diabetes: 6–10year Mean HB: 8–10 gm/dl Mean RBS: 400–550 Mean HBA1C:6–10% Mean ph: 7.00–7.24 Mean Na+: 135–145 Mean K+:3.5–5.5 Mean Creatinine: >1.0 Mean Blood urea: >18 Most common symptoms: nausea and vomiting > abdominal pain. Out of 50 patients 49 were discharged with proper guidance of treatment of DM and followup in medical opd and 1 pt was succumbed to death .