In the patients of ureteric stones, PCNL and hydronephrosis the use of ureteral stents is advised by the urologists. Stents are used to maintain ureteric patency and achieve free flow of urine, prevention of stricture following instrumentation. Patients with ureteric stent may present with symptoms like urgency, frequency, burning micturition, hematuria etc. The present study was conducted with an objective to determine and compare the effects of alpha blocker tamsulosin and anticholinergic drug solifenacin on the symptoms related to use of stents. The dose of drug Tamsulosin was 0.4 mg and that of solifenacin 5 mg and both were administered orally once a day for 14 days. The distribution of patients according relief to stent symptoms by Tamsulosin showed that majority of patients had relief from nausea and vomiting (33.33%), also the work performance was increased in 33.33% of patients, followed by dysuria (30%), urgency (26.67%), frequency (26.67%), nocturia (25%), pain (23.33%) and incontinence (23.33%). The distribution of patients according to relief to stent symptoms by Solifenacin showed that majority of patients had relief from urgency (53.33%), pain (26.67%) followed by frequency (25%), nausea & vomiting (25%), frequency (15%) and incontinence (11.67%). The difference in mean M–USSQ score pre–operative and after removal of stent was statistically significant. Irritative symptoms (frequency, dysuria, and urgency) may improve because of the alpha receptors blockage at the bladder trigone by tamsulosin, while solifenacin through its antimuscarinic effect shown to be useful in overactive bladder treatment.